() () . , , , , . - GISSI (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico) [l]. 11 806 , 5 905 () 1,5 , 5 901 . , , 11 %, - 13% (=0,0002). , , - 6 . : 12 17,2%, - 19,0% (=0,008). ISIS-2 (International Study of Infarct Survival) 17 187 : 8 592 , 8 595 - [2]. 5- 9,2%, - 12,0% (<0,0001). , 4 . , 4-24 , (<0,05). - ISAM (Intervenous Streptokinase in acute Myocardial Infarction) - 1 741 : 859 , 882 - . 21- 6,3% 7,1% []. , (), ASSET (Anglo-Scandinavian Study of Early Thrombolysis) [4]. 5011 , 2516 100 , 2 495 . 7,2% 9,8% . 6 LATE (Late Assessment of Thrombolytic Efficacy) [5]. 5711 . , , 35 8,86%, - 10,31%. , 6 12 , 25,6% , (=0,0229). , 12 24 , ( - 8,7%, - 9,2%). , , 6 , EMERAS (Estudio Multicentrico Estreptoquinasa Republicas de America del Sur) [6], - 2 080 7-12 1 791 13-24 1,5 . , , 7- 12- , , (11,7% 13,2% ). , 12 , , (11,4% 10,7% ). ^ () 1 258 (AIMS - APSAC Intervention Mortality Study) [7-8]. 30- , (), 6,4% 1
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